Curiosity Domains
Explore field notes and engineering explorations organized into deep subject verticals.
AI Agents & Orchestration
2 notesMulti-agent consensus, evaluation harnesses, tool calling, and MCP.
Cloudflare & Edge Systems
1 noteWorkers, Durable Objects, edge state, and zero-cold-start compute.
GraphRAG & Hybrid Retrieval
1 noteKnowledge graphs, vector embeddings, Qdrant, and rerankers.
Regulated AI & GxP Compliance
1 noteValidating probabilistic models, 21 CFR Part 11, CSA, and ISO 42001.
Laboratory & Bio Systems
2 notesLIMS, ELN, instrument connectivity, and automated bio-pipelines.
Local LLMs & Systems Engineering
1 noteQuantization, multi-token prediction (MTP), and low-latency inference.
AI Agents & Orchestration
2Deep explorations into autonomous agent loops, prompt compiler architectures (DSPy), deterministic guardrails, and production multi-agent systems.
Deconstructing Multi-Agent Consensus: Evaluator-Optimizer Loops vs Linear Chains
Why monolithic prompt chains degrade on complex tasks, how iterative evaluator-optimizer topologies converge, and practical patterns for production multi-agent systems.
Hardening Model Context Protocol (MCP) in Production & Regulated Environments
How to architect secure, audited MCP gateways for enterprise agent swarms: authorization scopes, rate limiting, and 21 CFR Part 11 compliance.
Cloudflare & Edge Systems
1Practical architectures leveraging Cloudflare Workers, Durable Objects SQLite persistence, Hyperdrive, Vectorize, and edge static asset serving.
GraphRAG & Hybrid Retrieval
1Architectural designs combining relational schemas, vector databases, and knowledge graphs to build hallucination-free retrieval pipelines.
Regulated AI & GxP Compliance
1Methodologies and frameworks for deploying artificial intelligence into life sciences, biopharma, and regulated FDA environments.
Laboratory & Bio Systems
2Modernizing life sciences IT portfolios: connecting lab instruments, electronic lab notebooks, MES, and high-throughput experimental workflows.
The State of Lab Automation in 2026: An Exhaustive Technical Deep Dive
A comprehensive analysis of lab automation in life sciences, biotech, and biopharma: liquid handling physics, robotic workcells, schedulers, SiLA 2 vs OPC UA LADS, and closed-loop self-driving labs.
Building Low-Latency Scientific Instrument Ingestion Pipelines for LIMS
How to connect physical chromatography and mass spectrometry systems to modern cloud/edge LIMS using OPC UA, edge gateways, and immutable audit trails.
Local LLMs & Systems Engineering
1Running small language models (SLMs) locally and at the edge: memory bandwidth constraints, KV cache compression, and hardware acceleration.